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Injectable medications to treat obesity and diabetes, known as GLP ones, have become increasingly popular, as I'm sure you've heard in recent years. But there may be a ceiling to how much weight patients can lose while using that seen as chief medical correspondent Dr. Sanjay Gupta has the story. What was the highest weight you ever had? The highest weight I ever had was over just slightly over ��400. You have this sort of reckoning, like, OK, I'm going to die. So Costalegre started taking a weight loss drug three years ago. How much weight did you lose? I've lost probably over 130 lbs. Wow. Do you want to lose more weight? I do, but losing more weight has become increasingly difficult. And of course the Zep bound and the Zepp bound, even on what is now the highest. Those of his GLP one drugs, this is the equivalent of 15 milligrams of Manjaro. I'm not losing 7 or 8 lbs a month anymore. People are using this word plateau when it comes to these medications. What does that term mean to you? Plateau basically means you're continuing to use the medication at the dosage that you've been using it, but the weight loss is stopped. Like you have reached sort of a ceiling or cap. Alright, you know the drill. Doctor Angela Fitch prescribes Costas medications. We don't have something that gives you greater than a 20 to 30% weight loss today on average. That 20% weight loss is a real plateau barrier that we have trouble kind of breaking through without more intensive intervention like surgery. As you lose weight, your body makes biochemicals that try to force your weight to go back up. But as you'll see, it's it's a heavy protein diet. If Costa wants to lose more weight at this point, that's going to have to mostly come from good nutrition. And lifestyle changes. I've moved away from just doing a lot of cardio to move into strength training and it's completely changed my life. You're doing everything right though. Getting plenty of sleep, eating right like Costas doing working out. You may still plateau on these medications. Plateau. It is inevitable. Yes. Is a plateau and goal to achieve or an obstacle to overcome? That is an excellent question and I think you know for now it is somewhat of both. Have to be happy with it being an end goal to achieve because that's the limit of our treatment today. But I think as a individual person we still continue to make changes. That you've lost 2.7 lbs of fat since last time. Even Costa is still losing fat around his midsection, which is better for his health. The hope is the future is different, that we have other treatments we can offer that could potentially breakthrough those plateaus, but until then, Costa will be an uncharted territory. I think that sometimes when we think about weight loss, plateau sounds like a bad thing. Like you get to that number and you're stuck there. By the way, like, let's be clear. If I stay at this weight and I can never lose another pound, I'm probably, you know, 100 times healthier than I was when I was 130 lbs heavier and probably have added years to my life. Everything you measure says you're healthy. Why do I lose more weight? I think that as I get older, it might be a challenge to continue to lose weight. You know, just looking historically at the data, the lower percentage body fat, the better. I certainly don't think I could lose 130 lbs. Another 130 lbs can't wither away to nothing. You can't wither away to nothing. Doctor Sanjay Gupta.